Endocrine Abstracts

Background: Our department cares for 273 children with type 1 diabetes (T1DM). All T1DM patients are issued with an uploadable glucose meter from diagnosis. 101 patients (37%) use insulin pump therapy and 126 (46%) use a continuous glucose monitoring device. Anecdotally we noted many patients were not uploading their data prior to coming to clinic. This contributed to reduced patient flow through diabetes clinics and also to reduced patient and carer engagement with their diab...

Background: Reports from several countries have suggested an increased incidence of diabetic ketoacidosis (DKA) at presentation of type 1 diabetes mellitus (T1DM) during the COVID-19 pandemic. Published data on this from the United Kingdom is sparse. We examined the frequency and severity of DKA at diagnosis of T1DM in children presenting to a university hospital during the first year of the pandemic in comparison to preceding years.Methods: In England, ...

Background: Current guidance recommends screening for coeliac disease (CD) at diagnosis of type 1 diabetes mellitus (T1DM) using measurement of serum anti tissue transglutaminase immunoglobulin A (tTG-IgA). It is recognized that tTG-IgA levels can fluctuate and there are reports of transient rises in tTG-IgA levels in response to acute stress, such as infection and acute coronary syndrome. The effect of diabetic ketoacidosis (DKA) on tTG-IgA has not been reported. We investiga...

Background: One in four children in England are now obese by school year 6. Childhood obesity is associated with significant co-morbidity including type 2 diabetes (T2DM), non-alcoholic fatty liver disease (NAFLD), obstructive sleep apnoea (OSA) and depression. NICE guidance suggests consideration of co-morbidity screening in children with body mass index (BMI) >98th centile but BMI does not accurately reflect adiposity in children owing to confounding effects of gender, h...

Background: A quarter of UK children now leave primary school obese. Childhood obesity is associated with significant comorbidity including obstructive sleep apnoea, type 2 diabetes, non-alcoholic fatty liver disease, hypertension and depression. We report our experience of using semaglutide, a weekly subcutaneous GLP1 receptor agonist, as a weight-loss adjunct for severely obese children in combination with dietary and lifestyle support from a multidisciplinary team.<p cl...

Background: Neonatal cortisol assessment is indicated in suspected adrenal insufficiency.Aims/objectives: Review of neonatal cortisol assessment within our Trust over seven years, to analyse trends, indications, outcomes; and relationships between gestational age (GA), birth weight (BW) and cortisol assessment.Methodology: From cortisol results on neonates (≤30 days age) between 2012–2018 (inclusive) we identified random...